reference : Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes

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/reference/133275d2-6318-44fd-b5be-2e3ab47b5d2b
Bibliographic fields
reftype Journal Article
Abstract The distribution and intensity of transmission of vector-borne pathogens can be strongly influenced by the competence of vectors. Vector competence, in turn, can be influenced by temperature and viral genetics. West Nile virus (WNV) was introduced into the United States of America in 1999 and subsequently spread throughout much of the Americas. Previously, we have shown that a novel genotype of WNV, WN02, first detected in 2001, spread across the US and was more efficient than the introduced genotype, NY99, at infecting, disseminating, and being transmitted by Culex mosquitoes. In the current study, we determined the relationship between temperature and time since feeding on the probability of transmitting each genotype of WNV. We found that the advantage of the WN02 genotype increases with the product of time and temperature. Thus, warmer temperatures would have facilitated the invasion of the WN02 genotype. In addition, we found that transmission of WNV accelerated sharply with increasing temperature, T, (best fit by a function of T(4)) showing that traditional degree-day models underestimate the impact of temperature on WNV transmission. This laboratory study suggests that both viral evolution and temperature help shape the distribution and intensity of transmission of WNV, and provides a model for predicting the impact of temperature and global warming on WNV transmission.
Author Kilpatrick, A. M.; Meola, M. A.; Moudy, R. M.; Kramer, L. D.
DOI 10.1371/journal.ppat.1000092
Date Jun
ISSN 1553-7374
Issue 6
Journal PLoS Pathogens
Keywords Animals; Culex/*virology; Insect Vectors/*virology; *Temperature; Time; West Nile Fever/*transmission; West Nile virus/*genetics
Notes Kilpatrick, A Marm Meola, Mark A Moudy, Robin M Kramer, Laura D eng 1R01AI069217-01/AI/NIAID NIH HHS/ N01-AI-2549/AI/NIAID NIH HHS/ T32-AI055429-03/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2008/06/28 09:00 PLoS Pathog. 2008 Jun 27;4(6):e1000092. doi: 10.1371/journal.ppat.1000092.
Pages e1000092
Title Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes
Volume 4
Year 2008
Bibliographic identifiers
.reference_type 0
_record_number 18009
_uuid 133275d2-6318-44fd-b5be-2e3ab47b5d2b