reference : Western equine encephalitis submergence: Lack of evidence for a decline in virus virulence

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/reference/1adbeb42-3948-4398-aa1f-1eee32bff0c3
Bibliographic fields
reftype Journal Article
Abstract The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1-2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the number of cases. Evaluation of 10 WEEV strains representing a variety of isolation locations, hosts, and all decades from the 1940's to the 1990's yielded no evidence of a decline in virulence. These results suggest that ecological factors affecting human and equine exposure should be investigated to explain the decline in WEE.
Author Forrester, N. L.; Kenney, J. L.; Deardorff, E.; Wang, E.; Weaver, S. C.
DOI 10.1016/j.virol.2008.08.012
Date Oct 25
ISSN 0042-6822
Issue 2
Journal Virology
Keywords Animals; Body Weight; Encephalitis Virus, Western Equine/*pathogenicity; Encephalomyelitis, Western Equine/epidemiology/*virology; Humans; Incidence; Mice; Survival Analysis; Virulence
Notes Forrester, Naomi L Kenney, Joan L Deardorff, Eleanor Wang, Eryu Weaver, Scott C eng T32 AI007526/AI/NIAID NIH HHS/ T32 AI060549/AI/NIAID NIH HHS/ T32 AI060549-04/AI/NIAID NIH HHS/ T32 AI060549-05/AI/NIAID NIH HHS/ U54 AI057156/AI/NIAID NIH HHS/ U54 AI057156-010003/AI/NIAID NIH HHS/ U54 AI057156-05S18269/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2008/09/20 09:00 Virology. 2008 Oct 25;380(2):170-2. doi: 10.1016/j.virol.2008.08.012. Epub 2008 Sep 17.
Pages 170-172
Title Western equine encephalitis submergence: Lack of evidence for a decline in virus virulence
Volume 380
Year 2008
Bibliographic identifiers
.reference_type 0
_record_number 18000
_uuid 1adbeb42-3948-4398-aa1f-1eee32bff0c3