reference : Exposure to particulate air pollution and cognitive decline in older women

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Bibliographic fields
reftype Journal Article
Abstract BACKGROUND: Chronic exposure to particulate air pollution may accelerate cognitive decline in older adults, although data on this association are limited. Our objective was to examine long-term exposure to particulate matter (PM) air pollution, both coarse ([PM 2.5-10 mum in diameter [PM(2.5-10)]) and fine (PM <2.5 mum in diameter [PM(2.5)]), in relation to cognitive decline. METHODS: The study population comprised the Nurses' Health Study Cognitive Cohort, which included 19,409 US women aged 70 to 81 years. We used geographic information system-based spatiotemporal smoothing models to estimate recent (1 month) and long-term (7-14 years) exposures to PM(2.5-10), and PM(2.5) preceding baseline cognitive testing (1995-2001) of participants residing in the contiguous United States. We used generalized estimating equation regression to estimate differences in the rate of cognitive decline across levels of PM(2.5-10) and PM(2.5) exposures. The main outcome measure was cognition, via validated telephone assessments, administered 3 times at approximately 2-year intervals, including tests of general cognition, verbal memory, category fluency, working memory, and attention. RESULTS: Higher levels of long-term exposure to both PM(2.5-10) and PM(2.5) were associated with significantly faster cognitive decline. Two-year decline on a global score was 0.020 (95% CI, -0.032 to -0.008) standard units worse per 10 mug/m(3) increment in PM(2.5-10) exposure and 0.018 (95% CI, -0.035 to -0.002) units worse per 10 mug/m(3) increment in PM(2.5) exposure. These differences in cognitive trajectory were similar to those between women in our cohort who were approximately 2 years apart in age, indicating that the effect of a 10-mug/m(3) increment in long-term PM exposure is cognitively equivalent to aging by approximately 2 years. CONCLUSION: Long-term exposure to PM(2.5-10) and PM(2.5) at levels typically experienced by many individuals in the United States is associated with significantly worse cognitive decline in older women.
Author Weuve, J.; Puett, R. C.; Schwartz, J.; Yanosky, J. D.; Laden, F.; Grodstein, F.
DOI 10.1001/archinternmed.2011.683
Date Feb 13
ISSN 1538-3679
Issue 3
Journal Archives of Internal Medicine
Keywords Aged; Cognition Disorders/epidemiology/*etiology; Environmental Exposure/*adverse effects/analysis; Female; Humans; Particle Size; Particulate Matter/*adverse effects/analysis; Prospective Studies
Language eng
Notes 1538-3679 Weuve, Jennifer Puett, Robin C Schwartz, Joel Yanosky, Jeff D Laden, Francine Grodstein, Francine P01 CA087969/CA/NCI NIH HHS/United States R01 ES017017/ES/NIEHS NIH HHS/United States R21 ES016829/ES/NIEHS NIH HHS/United States R24 HD041041/HD/NICHD NIH HHS/United States Journal Article United States Arch Intern Med. 2012 Feb 13;172(3):219-27. doi: 10.1001/archinternmed.2011.683.
Pages 219-227
Title Exposure to particulate air pollution and cognitive decline in older women
Volume 172
Year 2012
Bibliographic identifiers
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