reference : Environmental urban factors (air pollution and allergens) and the rising trends in allergic respiratory diseases

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/reference/3eabd82a-4bf8-4a43-9716-a019a02d9d8d
Bibliographic fields
reftype Journal Article
Abstract Respiratory allergic diseases such as rhinitis and bronchial asthma appear to be increasing worldwide, affecting in particular subjects living in urban areas, and the reasons for this increase are still largely unknown. Although the role played by air pollution has yet to be clarified, a body of evidence suggests that urbanization, with its high levels of vehicle emissions and a westernised lifestyle are linked to the rising frequency of these diseases observed in most industrialized countries. Laboratory studies confirm the epidemiological evidence that inhalation of some pollutants, either individually or in combination, adversely affect lung function in asthmatics. Air pollutants may not only increase the frequency and intensity of symptoms in already allergic patients but may promote airway sensitization to airborne allergens in predisposed subjects. By attaching to the surface of pollen grains and of plant-derived paucimicronic particles, pollutants can modify the morphology of these antigen-carrying agents and alter their allergenic potential. In addition, by inducing airway inflammation, pollutants may overcome the mucosal barrier and so "prime" allergen-induced responses. In other words airway mucosal damage and impaired mucociliary clearance induced by air pollution may facilitate the access of inhaled allergens to the cells of the immune system.
Author D’Amato, G.
Author Address Division of Pneumology and Allergology, Hospital A Cardarelli, 10 Via Rome Sirignano, I-80121 Naples, Italy.
DOI 10.1034/j.1398-9995.57.s72.5.x
Database Provider NLM
EPub Date 2002/07/30
ISSN 0105-4538 (Print) 0105-4538
Journal Allergy
Keywords Air Pollutants/*adverse effects/analysis; *Allergens; Humans; Pollen; Respiratory Hypersensitivity/*epidemiology/etiology; *Urban Health
Language eng
Pages 30-33
Title Environmental urban factors (air pollution and allergens) and the rising trends in allergic respiratory diseases
Volume 57 Suppl 72
Year 2002
Bibliographic identifiers
_record_number 18643
_uuid 3eabd82a-4bf8-4a43-9716-a019a02d9d8d