reference : Geographic variation in the relationship between human Lyme disease incidence and density of infected host-seeking Ixodes scapularis nymphs in the eastern United States

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/reference/471591cc-8f0b-4a50-bba0-330451700a54
Bibliographic fields
reftype Journal Article
Abstract Prevention and control of Lyme disease is difficult because of the complex biology of the pathogen's (Borrelia burgdorferi) vector (Ixocles scapularis) and multiple reservoir hosts with varying degrees of competence. Cost-effective implementation of tick- and host-targeted control methods requires an understanding of the relationship between pathogen prevalence in nymphs, nymph abundance, and incidence of human cases of Lyme disease. We quantified the relationship between estimated acarological risk and human incidence using county-level human case data and nymphal prevalence data from field-derived estimates in 36 eastern states. The estimated density of infected nymphs (mDIN) was significantly correlated with human incidence (r = 0.69). The relationship was strongest in high-prevalence areas, but it varied by region and state, partly because of the distribution of B. burgdorferi genotypes. More information is needed in several high-prevalence states before DIN can be used for cost-effectiveness analyses.
Author Pepin, K. M.; Eisen, R. J.; Mead, P. S.; Piesman, J.; Fish, D.; Hoen, A. G.; Barbour, A. G.; Hamer, S.; Diuk-Wasser, M. A.
DOI 10.4269/ajtmh.2012.11-0630
Date Jun
ISSN 0002-9637
Issue 6
Journal The American Journal of Tropical Medicine and Hygiene
Keywords burgdorferi sensu-stricto; tick-borne diseases; climate-based model; borrelia-burgdorferi; hematogenous dissemination; forest fragmentation; human risk; surveillance; predicts; vector
Language English
Notes 952IH Times Cited:10 Cited References Count:41
Pages 1062-1071
Title Geographic variation in the relationship between human Lyme disease incidence and density of infected host-seeking Ixodes scapularis nymphs in the eastern United States
Volume 86
Year 2012
Bibliographic identifiers
.reference_type 0
_record_number 17748
_uuid 471591cc-8f0b-4a50-bba0-330451700a54