reference : Temperature, myocardial infarction, and mortality: Effect modification by individual- and area-level characteristics

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/reference/77048fd9-a2e6-4284-89d2-cb70de60eb14
Bibliographic fields
reftype Journal Article
Abstract BACKGROUND: Although several studies have examined associations between temperature and cardiovascular-disease-related mortality, fewer have investigated the association between temperature and the development of acute myocardial infarction (MI). Moreover, little is known about who is most susceptible to the effects of temperature. METHODS: We analyzed data from the Worcester Heart Attack Study, a community-wide investigation of acute MI in residents of the Worcester (MA) metropolitan area. We used a case-crossover approach to examine the association of apparent temperature with acute MI occurrence and with all-cause in-hospital and postdischarge mortality. We examined effect modification by sociodemographic characteristics, medical history, clinical complications, and physical environment. RESULTS: A decrease in an interquartile range in apparent temperature was associated with an increased risk of acute MI on the same day (hazard ratio = 1.15 [95% confidence interval = 1.01-1.31]). Extreme cold during the 2 days prior was associated with an increased risk of acute MI (1.36 [1.07-1.74]). Extreme heat during the 2 days prior was also associated with an increased risk of mortality (1.44 [1.06-1.96]). Persons living in areas with greater poverty were more susceptible to heat. CONCLUSIONS: Exposure to cold increased the risk of acute MI, and exposure to heat increased the risk of dying after an acute MI. Local area vulnerability should be accounted for as cities prepare to adapt to weather fluctuations as a result of climate change.
Author Madrigano, J.; Mittleman, M. A.; Baccarelli, A.; Goldberg, R.; Melly, S.; von Klot, S.; Schwartz, J.
DOI 10.1097/EDE.0b013e3182878397
Date May
ISSN 1531-5487
Issue 3
Journal Epidemiology
Keywords Aged; Aged, 80 and over; Cold Temperature/ adverse effects; Cross-Over Studies; Effect Modifier, Epidemiologic; Female; Follow-Up Studies; Hot Temperature/ adverse effects; Humans; Logistic Models; Male; Massachusetts/epidemiology; Middle Aged; Myocardial Infarction/ etiology/mortality; Poverty Areas; Risk Factors; Urban Health
Language eng
Notes Madrigano, Jaime Mittleman, Murray A Baccarelli, Andrea Goldberg, Robert Melly, Steven von Klot, Stephanie Schwartz, Joel R01 HL35434/HL/NHLBI NIH HHS/United States T32ES016645/ES/NIEHS NIH HHS/United States T32ES07069/ES/NIEHS NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Epidemiology. 2013 May;24(3):439-46. doi: 10.1097/EDE.0b013e3182878397.
Pages 439-446
Title Temperature, myocardial infarction, and mortality: Effect modification by individual- and area-level characteristics
Volume 24
Year 2013
Bibliographic identifiers
.reference_type 0
_record_number 4787
_uuid 77048fd9-a2e6-4284-89d2-cb70de60eb14