reference : West Nile fever characteristics among viremic persons identified through blood donor screening

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Bibliographic fields
reftype Journal Article
Abstract Nucleic acid testing (NAT) of blood donors provides opportunities for identifying West Nile virus (WNV)-infected persons before symptoms develop and for characterizing subsequent illness. From June 2003 through 2008, the American Red Cross performed follow-up interviews with and additional laboratory testing for 1436 donors whose donations had initial test results that were reactive for WNV RNA; 821 of the donors were subsequently confirmed to have WNV infection, and the remainder were unconfirmed or determined to have false-positive results. Symptoms attributed to WNV infection were determined by comparing symptom frequency among 576 donors identified with early WNV infection (immunoglobulin M antibody negative) and those with unconfirmed infection. We estimate that 26% of WNV-infected persons become symptomatic, defined by the presence of at least 3 of 8 indicator symptoms. Nearly one-half of symptomatic persons sought medical care; only 5% received a diagnosis of WNV infection. Female subjects and persons with higher viral loads detected in the index donation were more likely than other subjects to develop symptoms.
Author Zou, S.; Foster, G. A.; Dodd, R. Y.; Petersen, L. R.; Stramer, S. L.
DOI 10.1086/656602
Date Nov 1
ISSN 1537-6613
Issue 9
Journal The Journal of Infectious Diseases
Keywords Adult; Aged; *Blood Donors; Female; Humans; Male; *Mass Screening; Middle Aged; RNA, Viral/*blood; United States; Viral Load; West Nile Fever/*diagnosis/*pathology; West Nile virus/*genetics
Notes Zou, Shimian Foster, Gregory A Dodd, Roger Y Petersen, Lyle R Stramer, Susan L eng 2010/09/30 06:00 J Infect Dis. 2010 Nov 1;202(9):1354-61. doi: 10.1086/656602.
Pages 1354-1361
Title West Nile fever characteristics among viremic persons identified through blood donor screening
Volume 202
Year 2010
Bibliographic identifiers
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_record_number 18046
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