reference : Emergence and persistence of hantaviruses

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Abstract Hantaviral diseases have been recognized for hundreds of years but, until 1976, they had not been associated with an infectious agent. When Lee and colleagues isolated what is now known as Hantaan virus, the techniques they introduced allowed further investigations into the etiology of the classical hantavirus disease, hemorrhagic fever with renal syndrome (HFRS), now known to be caused by any of multiple hantaviruses. The discovery of hantavirus pulmonary syndrome (HPS) in the New World, and that it also can be caused by any of multiple hantaviruses (family Bunyaviridae, genus Hantavirus), has opened an entire field of epidemiologic, virologic, molecular, behavioral, and ecologic studies of these viruses. There appears to be a single hantavirus-single rodent host association, such that understanding the idiosyncrasies of each rodent host species and the ecologic variables that affect them are recognized as critical if we are to reduce human risk for infection. This chapter summarizes what is known about hantaviruses with regard to history of these viruses, their taxonomy, recognized geographical distribution, ecologic factors impacting their maintenance and spread of hantaviruses, effect of rodent behavior on hantavirus transmission, influence of host factors on susceptibility to and transmission of hantaviruses, and transmission of hantaviruses from rodents to humans. In addition, we summarize all these complexities and provide suggestions for future research directions.
Author Klein, S. L.; Calisher, C. H.
Book Title Wildlife and Emerging Zoonotic Diseases: The Biology, Circumstances and Consequences of Cross-Species Transmission
DOI 10.1007/978-3-540-70962-6_10
Editor Childs, J. E.; Mackenzie, J.S.; Richt, J.A.
ISBN 0070-217X (Print) 0070-217x
Keywords Age Factors; Animals; Animals, Wild/virology; Disease Reservoirs/*veterinary/virology; *Hantavirus/classification; Hantavirus Infections/epidemiology/immunology/*transmission/*veterinary; Humans; Phylogeny; Rodent Diseases/epidemiology/immunology/transmission/virology; Rodentia; Sex Factors; Species Specificity; *Zoonoses
Language eng
Notes Klein, S L Calisher, C H Journal Article Review Germany Curr Top Microbiol Immunol. 2007;315:217-52.
Pages 217-252
Place Published Berlin
Publisher Springer-Verlag
Title Emergence and persistence of hantaviruses
Volume 315
Year 2007
Bibliographic identifiers
.reference_type 7
_record_number 18692
_uuid d774237d-5d86-4dde-91ca-8b51dabf6106