reference : A population-based case-control study of extreme summer temperature and birth defects

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Bibliographic fields
reftype Journal Article
Abstract BACKGROUND: Although hyperthermia is a recognized animal teratogen and maternal fever has been associated with birth defects in humans, data on the relationship between high environmental temperatures and birth defects are limited. OBJECTIVE: To determine whether pregnancies are potentially vulnerable to the weather extremes anticipated with climate change, we evaluated the relationship between extreme summer temperature and the occurrence of birth defects. METHODS: We performed a population-based case-control study by linking the New York State Congenital Malformations Registry to birth certificates for the years 1992-2006. We selected nonmalformed infants from a 10% random sample of live births as controls. We assigned meteorologic data based on maternal residence at birth, summarized universal apparent temperature (UAT; degrees Fahrenheit) across the critical period of embryogenesis, and estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) with multivariable logistic regression, controlling for confounders available on the birth certificate. RESULTS: Among 6,422 cases and 59,328 controls that shared at least 1 week of the critical period in summer, a 5-degree increase in mean daily minimum UAT was significantly associated with congenital cataracts (aOR = 1.51; 95% CI: 1.14, 1.99). Congenital cataracts were significantly associated with all ambient temperature indicators as well: heat wave, number of heat waves, and number of days above the 90th percentile. Inconsistent associations with a subset of temperature indicators were observed for renal agenesis/hypoplasia (positive) and anophthalmia/microphthalmia and gastroschisis (negative). CONCLUSIONS: We found positive and consistent associations between multiple heat indicators during the relevant developmental window and congenital cataracts which should be confirmed with other data sources.
Author Van Zutphen, A. R.; Lin, S.; Fletcher, B. A.; Hwang, S.-A.
DOI 10.1289/ehp.1104671
Date Oct
ISSN 1552-9924
Issue 10
Journal Environmental Health Perspectives
Keywords Adult; Case-Control Studies; Congenital Abnormalities/ epidemiology/ etiology; Female; Hot Temperature; Humans; Infant; Infant, Newborn; Logistic Models; Male; New York/epidemiology; Risk Factors; Seasons; Young Adult
Language eng
Notes Van Zutphen, Alissa R Lin, Shao Fletcher, Barbara A Hwang, Syni-An 1U38EH000184-05/EH/NCEH CDC HHS/United States 5U01EH000396-02/EH/NCEH CDC HHS/United States Research Support, U.S. Gov't, P.H.S. United States Environ Health Perspect. 2012 Oct;120(10):1443-9. doi: 10.1289/ehp.1104671. Epub 2012 Jun 27.
Pages 1443-1449
Title A population-based case-control study of extreme summer temperature and birth defects
Volume 120
Year 2012
Bibliographic identifiers
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_record_number 5316
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