reference : Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly

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/reference/f97a9f54-fd6c-471e-9bb2-f1459f41c403
Bibliographic fields
reftype Journal Article
Abstract Animal studies have suggested that fine particulate matter (PM) can translocate from the upper respiratory tract to the brain and cause brain inflammation. Brain inflammation is involved in the pathogenesis of neurodegenerative diseases. Hypothesizing therefore that long-term exposure to fine PM might contribute to the development of Alzheimer's disease (AD), the objective of this study was to investigate the association between exposure to fine PM and mild cognitive impairment (MCI) which is associated with a high risk of progression to AD. A study group of 399 women aged 68-79 years who lived for more than 20 years at the same residential address has been assessed for long-term exposure to PM and tested for MCI. The exposure assessment comprised background concentration of PM(10) and traffic-related PM indicated by the distance of the residential address to the next busy road. The women were assessed for MCI by a battery of several neuropsychological tests and their odor identification ability. Consistent effects of traffic-related air pollution exposure on test performances including a dose-response relation were found. The associations were adjusted for potential confounders using regression analysis. These results indicate that chronic exposure to traffic-related PM may be involved in the pathogenesis of AD.
Author Ranft, U.; Schikowski, T.; Sugiri, D.; Krutmann, J.; Kramer, U.
DOI 10.1016/j.envres.2009.08.003
Date Nov
ISSN 0013-9351
Issue 8
Journal Environmental Research
Keywords Aged; Cognition Disorders/*chemically induced; *Environmental Exposure; Humans; Vehicle Emissions/*toxicity
Language eng
Notes 1096-0953 Ranft, Ulrich Schikowski, Tamara Sugiri, Dorothee Krutmann, Jean Kramer, Ursula Journal Article Research Support, Non-U.S. Gov't United States Environ Res. 2009 Nov;109(8):1004-11. doi: 10.1016/j.envres.2009.08.003. Epub 2009 Sep 4.
Pages 1004-1011
Title Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly
Volume 109
Year 2009
Bibliographic identifiers
.reference_type 0
_record_number 18164
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