reference : Pollutants and asthma: Role of air toxics

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reftype Journal Article
Abstract Asthma is a disease characterized by intermittent bronchoconstriction due to increased airway reactivity to both allergic and nonallergic stimuli. Most asthma exacerbations that result in hospitalization are associated with viral upper respiratory tract infections. Such infections typically induce T-helper type 1 (T(H)1) responses in the airway, involving activation of nuclear factor-kappaB (NF-Kappa B). However, a more recently appreciated cause of asthma exacerbation is exposure to pollutants, including ozone and various components of particulate matter (PM), including transition metals, diesel exhaust, and biologicals such as endotoxin. Although the role of air toxics in asthma pathogenesis remains incompletely examined, many components of PM that are active exacerbants of asthma are also prominent air toxics (metal ions and organic residues). These agents have been observed to activate NF-Kappa B. Reviewed in this article are the actions of specific air pollutants on airway inflammation in humans and potential common response pathways for ozone, PM, and several air toxics.
Author Peden, D. B.
Date Aug
ISSN 1552-9924
Journal Environmental Health Perspectives
Keywords Air Pollutants/*adverse effects; Asthma/*etiology/immunology; Endotoxins/adverse effects; Humans; Inflammation/*physiopathology; Metals, Heavy/adverse effects; Organic Chemicals/adverse effects; Particle Size; Respiratory Tract Infections/complications/virology; T-Lymphocytes, Helper-Inducer/*immunology
Language eng
Notes Peden, David B Journal Article Review United States Environ Health Perspect. 2002 Aug;110 Suppl 4:565-8.
PMC 1241207
Pages 565-568
Title Pollutants and asthma: Role of air toxics
Volume 110 Suppl 4
Year 2002
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.reference_type 0
_record_number 18267
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