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reference : Western equine encephalitis submergence: Lack of evidence for a decline in virus virulence
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/report/usgcrp-climate-human-health-assessment-2016/chapter/vectorborne-diseases/reference/1adbeb42-3948-4398-aa1f-1eee32bff0c3.html
/report/usgcrp-climate-human-health-assessment-2016/chapter/vectorborne-diseases/reference/1adbeb42-3948-4398-aa1f-1eee32bff0c3.html
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- /reference/1adbeb42-3948-4398-aa1f-1eee32bff0c3
- /report/usgcrp-climate-human-health-assessment-2016/reference/1adbeb42-3948-4398-aa1f-1eee32bff0c3
- /report/usgcrp-climate-human-health-assessment-2016/chapter/vectorborne-diseases/reference/1adbeb42-3948-4398-aa1f-1eee32bff0c3
Referenced Publication:
article
| reftype | Journal Article |
| Abstract | The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1-2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the number of cases. Evaluation of 10 WEEV strains representing a variety of isolation locations, hosts, and all decades from the 1940's to the 1990's yielded no evidence of a decline in virulence. These results suggest that ecological factors affecting human and equine exposure should be investigated to explain the decline in WEE. |
| Author | Forrester, N. L.; Kenney, J. L.; Deardorff, E.; Wang, E.; Weaver, S. C. |
| DOI | 10.1016/j.virol.2008.08.012 |
| Date | Oct 25 |
| ISSN | 0042-6822 |
| Issue | 2 |
| Journal | Virology |
| Keywords | Animals; Body Weight; Encephalitis Virus, Western Equine/*pathogenicity; Encephalomyelitis, Western Equine/epidemiology/*virology; Humans; Incidence; Mice; Survival Analysis; Virulence |
| Notes | Forrester, Naomi L Kenney, Joan L Deardorff, Eleanor Wang, Eryu Weaver, Scott C eng T32 AI007526/AI/NIAID NIH HHS/ T32 AI060549/AI/NIAID NIH HHS/ T32 AI060549-04/AI/NIAID NIH HHS/ T32 AI060549-05/AI/NIAID NIH HHS/ U54 AI057156/AI/NIAID NIH HHS/ U54 AI057156-010003/AI/NIAID NIH HHS/ U54 AI057156-05S18269/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2008/09/20 09:00 Virology. 2008 Oct 25;380(2):170-2. doi: 10.1016/j.virol.2008.08.012. Epub 2008 Sep 17. |
| Pages | 170-172 |
| Title | Western equine encephalitis submergence: Lack of evidence for a decline in virus virulence |
| Volume | 380 |
| Year | 2008 |
| .reference_type | 0 |
| _record_number | 18000 |
| _uuid | 1adbeb42-3948-4398-aa1f-1eee32bff0c3 |
