reference : Key role of T cell defects in age-related vulnerability to West Nile virus

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reftype Journal Article
Abstract West Nile virus (WNV) infection causes a life-threatening meningoencephalitis that becomes increasingly more prevalent over the age of 50 and is 40-50x more prevalent in people over the age of 70, compared with adults under the age of 40. In a mouse model of age-related vulnerability to WNV, we demonstrate that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV. Specific age-related defects in T cell responses against dominant WNV epitopes were detected at the level of cytokine and lytic granule production, each of which are essential for resistance against WNV, and in the ability to generate multifunctional anti-WNV effector T cells, which are believed to be critical for robust antiviral immunity. In contrast, at the peak of the response, old and adult T cells exhibited superimposable peptide sensitivity. Most importantly, although the adult CD4 or CD8 T cells readily protected immunodeficient mice upon adoptive transfer, old T cells of either subset were unable to provide WNV-specific protection. Consistent with a profound qualitative and quantitative defect in T cell immunity, old brains contained at least 12x fewer total effector CD8 T cells compared with adult mice at the peak of brain infection. These findings identify potential targets for immunomodulation and treatment to combat lethal WNV infection in the elderly.
Author Brien, James D.; Uhrlaub, Jennifer L.; Hirsch, Alec; Wiley, Clayton A.; Nikolich-┼Żugich, Janko
DOI 10.1084/jem.20090222
Date Nov 23
ISSN 1540-9538
Issue 12
Journal The Journal of Experimental Medicine
Keywords Adoptive Transfer; Adult; Aged; Aging/genetics/*immunology/pathology; Animals; Brain/*immunology/pathology/virology; CD4-Positive T-Lymphocytes/*immunology/pathology; CD8-Positive T-Lymphocytes/*immunology/pathology; Cytokines/genetics/immunology; Disease Models, Animal; Epitopes, T-Lymphocyte/genetics/immunology; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Middle Aged; West Nile Fever/genetics/*immunology/pathology; West Nile virus/*immunology
Notes Brien, James D Uhrlaub, Jennifer L Hirsch, Alec Wiley, Clayton A Nikolich-Zugich, Janko eng AI 81860/AI/NIAID NIH HHS/ HHSN266200500027C/N01 AI50027/AI/NIAID NIH HHS/ N01 50027/PHS HHS/ RR0163/RR/NCRR NIH HHS/ T32 AI007472/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural 2009/11/11 06:00 J Exp Med. 2009 Nov 23;206(12):2735-45. doi: 10.1084/jem.20090222. Epub 2009 Nov 9.
Pages 2735-2745
Title Key role of T cell defects in age-related vulnerability to West Nile virus
Volume 206
Year 2009
Bibliographic identifiers
.reference_type 0
_record_number 17993
_uuid 65d30924-1b63-46f1-9ca1-ee487643d52c