reference : Active and passive surveillance and phylogenetic analysis of Borrelia burgdorferi elucidate the process of Lyme disease risk emergence in Canada

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/report/usgcrp-climate-human-health-assessment-2016/reference/2970d11e-802d-4df1-b0b4-e1f0684e7425
Bibliographic fields
reftype Journal Article
Abstract BACKGROUND: Northward expansion of the tick Ixodes scapularis is driving Lyme disease (LD) emergence in Canada. Information on mechanisms involved is needed to enhance surveillance and identify where LD risk is emerging. OBJECTIVES: We used passive and active surveillance and phylogeographic analysis of Borrelia burgdorferi to investigate LD risk emergence in Quebec. METHODS: In active surveillance, we collected ticks from the environment and from captured rodents. B. burgdorferi transmission was detected by serological analysis of rodents and by polymerase chain reaction assays of ticks. Spatiotemporal trends in passive surveillance data assisted interpretation of active surveillance. Multilocus sequence typing (MLST) of B. burgdorferi in ticks identified likely source locations of B. burgdorferi. RESULTS: In active surveillance, we found I. scapularis at 55% of sites, and we were more likely to find them at sites with a warmer climate. B. burgdorferi was identified at 13 I. scapularis-positive sites, but infection prevalence in ticks and animal hosts was low. Low infection prevalence in ticks submitted in passive surveillance after 2004-from the tick-positive regions identified in active surveillance-coincided with an exponential increase in tick submissions during this time. MLST analysis suggested recent introduction of B. burgdorferi from the northeastern United States. CONCLUSIONS: These data are consistent with I. scapularis ticks dispersed from the United States by migratory birds, founding populations where the climate is warmest, and then establishment of B. burgdorferi from the United States several years after I. scapularis have established. These observations provide vital information for public health to minimize the impact of LD in Canada.
Accession Number 20421192
Author Ogden, N. H. Bouchard, C. Kurtenbach, K. Margos, G. Lindsay, L. R. Trudel, L. Nguon, S. Milord, F.
Author Address Centre for Food-Borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada. nicholas_ogden@phac-aspc.gc.ca
DOI 10.1289/ehp.0901766
Database Provider NLM
Date Jul
Epub Date 2010/04/28
ISSN 1552-9924
Issue 7
Journal Environmental Health Perspectives
Keywords Animals Borrelia burgdorferi/classification/ genetics Cluster Analysis Communicable Diseases, Emerging/ epidemiology/microbiology Demography Genetic Variation Humans Ixodes/ microbiology Logistic Models Lyme Disease/ epidemiology/microbiology Phylogeny Population Surveillance/methods Quebec/epidemiology Rodentia/ parasitology Sequence Analysis, DNA Tick Infestations/epidemiology/ veterinary
Language eng
Notes Ogden, Nicholas H Bouchard, Catherine Kurtenbach, Klaus Margos, Gabriele Lindsay, L Robbin Trudel, Louise Nguon, Soulyvane Milord, Francois Research Support, Non-U.S. Gov't United States Environ Health Perspect. 2010 Jul;118(7):909-14. doi: 10.1289/ehp.0901766. Epub 2010 Mar 25.
PMCID 2920908
Pages 909-914
Title Active and passive surveillance and phylogenetic analysis of Borrelia burgdorferi elucidate the process of Lyme disease risk emergence in Canada
URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920908/pdf/ehp-118-909.pdf
Volume 118
Year 2010
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