reference : West Nile virus infections projected from blood donor screening data, United States, 2003

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Bibliographic fields
reftype Journal Article
Abstract National blood donor screening for West Nile virus (WNV) RNA using minipool nucleic acid amplification testing (MP-NAT) was implemented in the United States in July 2003. We compiled national NAT yield data and performed WNV immunoglobulin M (IgM) testing in 1 WNV-epidemic region (North Dakota). State-specific MP-NAT yield, antibody seroprevalence, and the average time RNA is detectable by MP-NAT were used to estimate incident infections in 2003. WNV donor screening yielded 944 confirmed viremic donors. MP-NAT yield peaked in August with >0.5% of donations positive for WNV RNA in 4 states. Peak IgM seroprevalence for North Dakota was 5.2% in late September. The average time viremia is detectable by MP-NAT was 6.9 days (95% confidence interval [CI] 3.0-10.7). An estimated 735,000 (95% CI 322,000-1,147,000) infections occurred in 2003, with 256 (95% CI 112-401) infections per neuroinvasive case. In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population.
Author Busch, M. P.; Wright, D. J.; Custer, B.; Tobler, L. H.; Stramer, S. L.; Kleinman, S. H.; Prince, H. E.; Bianco, C.; Foster, G.; Petersen, L. R.; Nemo, G.; Glynn, S. A.
DOI 10.3201/eid1203.051287
Date Mar
ISSN 1080-6059
Issue 3
Journal Emerging Infectious Diseases
Keywords *Blood Donors; Humans; Incidence; *Mass Screening; RNA, Viral/blood; Seasons; Sensitivity and Specificity; Time Factors; United States/epidemiology; West Nile Fever/*blood/*epidemiology; West Nile virus/isolation & purification
Notes Busch, Michael P Wright, David J Custer, Brian Tobler, Leslie H Stramer, Susan L Kleinman, Steven H Prince, Harry E Bianco, Celso Foster, Gregory Petersen, Lyle R Nemo, George Glynn, Simone A eng N01-HB-47114/HB/NHLBI NIH HHS/ N01-HB-97078/HB/NHLBI NIH HHS/ N01-HB-97079/HB/NHLBI NIH HHS/ N01-HB-97080/HB/NHLBI NIH HHS/ N01-HB-97081/HB/NHLBI NIH HHS/ N01-HB-97082/HB/NHLBI NIH HHS/ Research Support, N.I.H., Extramural 2006/05/18 09:00 Emerg Infect Dis. 2006 Mar;12(3):395-402.
Pages 395-402
Title West Nile virus infections projected from blood donor screening data, United States, 2003
Volume 12
Year 2006
Bibliographic identifiers
.reference_type 0
_record_number 17995
_uuid 2f0bf1e9-15d4-45a6-bd9e-9092ffabe3c3